Reaktion #7577

Reaktionsgleichung

sodium hydroxide

4-fluoro-2-methyl-5-nitrophenol

→

2-fluoro-5-hydroxy-4-methylaniline

Ausbeute 47.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux for 4 hours
3. 3
   Temperaturto cool
4. 4
   Extraktionextracted with ethyl acetate (100 ml)
5. 5
   ExtraktionThe ethyl acetate extract
6. 6
   Trocknenwas dried (MgSO4)
7. 7
   Sonstigethe solvent removed by evaporation

Vorschrift

A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was heated at reflux for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.

Quelle