Reaktion #7575

Reaktionsgleichung

Methyl chloroformate

4-fluoro-2-methylphenol

→

4-fluoro-2-methylphenyl methyl carbonate

Ausbeute 78.4%

Lösungsmittel

sodium hydroxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate (100 ml)
2. 2
   ExtraktionThe ethyl acetate extract
3. 3
   Waschenwas washed with water (100 ml)
4. 4
   Trocknendried (MgSO4)
5. 5
   Sonstigethe solvent removed by evaporation

Vorschrift

Methyl chloroformate (6.8 ml, 88 mmol) was added over 30 minutes to a solution of 4-fluoro-2-methylphenol (10 g, 79 mmol) in 6% aqueous sodium hydroxide solution at 0° C. The mixture was stirred for 2 hours, then extracted with ethyl acetate (100 ml). The ethyl acetate extract was washed with water (100 ml) and dried (MgSO4) and the solvent removed by evaporation to give 4-fluoro-2-methylphenyl methyl carbonate (11.4 g, 78%) as an oil.

Quelle