Reaktion #75737

Reaktionsgleichung

Dimethylformamide diethyl acetal

3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylic acid

→

ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthen washed six times with water (500 mL)
2. 2
   Trocknendried over magnesium
3. 3
   Einengenconcentrated under vacuum
4. 4
   SonstigeThe residue was recrystallized from ethyl acetate/hexanes

Vorschrift

Dimethylformamide diethyl acetal (46 mL) was added to a suspension of 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylic acid (36 g) in dichloromethane (800 mL). The reaction mixture was stirred at ambient temperature overnight then washed six times with water (500 mL), dried over magnesium sulfated, and concentrated under vacuum. The residue was recrystallized from ethyl acetate/hexanes to provide 40 g of ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylate as a solid.

Quelle