Reaktion #75728

Reaktionsgleichung

2-Aminonicotinic acid

acetic anhydride

→

2-methyl-4H-pyrido[2,3-d][1,3]oxazin-4-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthen heated
2. 2
   Temperaturat reflux for 2 hours
3. 3
   EinengenThe reaction mixture was concentrated under vacuum
4. 4
   Filtrationthen filtered

Vorschrift

2-Aminonicotinic acid (5 g, 36 mmole) was suspended in acetic anhydride (25 mL) then heated at reflux for 2 hours. The reaction mixture was concentrated under vacuum. The resulting residue was slurried with ethyl acetate and hexane then filtered to provide 5 g of 2-methyl-4H-pyrido[2,3-d][1,3]oxazin-4-one.

Quelle