Reaktion #75672
ord-638a400385b2400ca3182ab90c300c27
Reaktionsgleichung
sodium hydroxide
3,5-dichloroaniline
ethylglyoxalate
4-bromostyrene
trifluoroacetic acid
→
Compound 40
4-(4-bromophenyl)-5,7-dichloro-1 ,2,3,4-tetrahydroquinoline-2-carboxylic Acid
Reagenzien
Keine
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
Compound 40 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 4-bromostyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.