Reaktion #75663

Reaktionsgleichung

sodium hydroxide

3,5-dichloroaniline

ethylglyoxalate

4-fluorostyrene

trifluoroacetic acid

→

Compound 31

5,7-dichloro-4-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

Lösungsmittel

ethanol

acetonitrile

Reaktionsbedingungen

Vorschrift

Compound 31 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 4-fluorostyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

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