Reaktion #75650

Reaktionsgleichung

sodium hydroxide

3,5-dichloroaniline

ethylglyoxalate

3-methylstyrene

trifluoroacetic acid

→

Compound 18

5,7-dichloro-4-m-tolyl-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

Lösungsmittel

ethanol

acetonitrile

Reaktionsbedingungen

Vorschrift

Compound 18 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 3-methylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

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