Reaktion #75590

Reaktionsgleichung

potassium hydrogen fluoride

benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate

→

title compound

Ausbeute 87.0%

Benzyl 4-fluoromethyl-4-hydroxy-1-piperidinecarboxylate

Ausbeute 87.0%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Filtrationit was filtered through Celite
3. 3
   SonstigeThe filtrate was evaporated

Vorschrift

3.2 g of potassium hydrogen fluoride and 610 mg tetra-n-butyl ammonium dihydrogen trifluoride were added to 5 g of benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate, and it was stirred at 120° C. for 7 hr. After cooling, methylene chloride was added thereto and it was filtered through Celite. The filtrate was evaporated, and the resulting residue was subjected to silica gel column chromatography to give 4.7 g of the title compound.

Quelle