Reaktion #7559

Reaktionsgleichung

4-hydroxy-6,7-dimethoxycinnoline

thionyl chloride

→

4-chloro-6,7-dimethoxycinnoline hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 3 hours
2. 2
   TemperaturAfter cooling
3. 3
   Sonstigeevaporating the excess thionyl chloride
4. 4
   Sonstigethe solid was triturated with ether
5. 5
   Filtrationfiltered

Vorschrift

The starting material, 4-chloro-6,7-dimethoxycinnoline hydrochloride was obtained by heating a solution of 4-hydroxy-6,7-dimethoxycinnoline (1 g, 4.8 mmol) in thionyl chloride (20 ml) containing DMF (2 drops) at reflux for 3 hours. After cooling and evaporating the excess thionyl chloride, the solid was triturated with ether and filtered to give 4-chloro-6,7-dimethoxycinnoline hydrochloride (1.2 g, quantitative).

Quelle