Reaktion #75576

Reaktionsgleichung

Potassium carbonate

hexamethylene tetramine

N-(4-methoxybenzyl)phthalimide

trifluoroacetic acid

→

N-(3-formyl-4-methoxybenzyl)phthalimide

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturunder reflux for 4 hr
3. 3
   TemperaturThe reaction solution was cooled to 0° C.
4. 4
   Filtrationthe resulting crystals were collected by filtration
5. 5
   SonstigeThe crystals were dried

Vorschrift

18 g of hexamethylene tetramine was added little by little to a mixture of 31 g N-(4-methoxybenzyl)phthalimide and 100 ml trifluoroacetic acid, stirred at room temperature for 1 hr, and then heated under reflux for 4 hr. The reaction solution was cooled to 0° C., and water was added thereto. Potassium carbonate was added thereto and the resulting crystals were collected by filtration. The crystals were dried to give 20 g of N-(3-formyl-4-methoxybenzyl)phthalimide.

Quelle