Reaktion #75541

Reaktionsgleichung

N-[2-hydroxy-1-(4-methyl-piperazin-1-ylmethyl)ethyl] acetamide

hydrochloric acid

→

2-amino-3-(4-methyl-piperazinyl)-1-propanol, hydrochloride

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling at a temperature of about 60° C.
2. 2
   Filtrationthe reaction medium is filtered
3. 3
   Einengenthe filtrate is concentrated under reduced pressure (2 kPa) at a temperature of about 60° C

Vorschrift

A suspension of 0.89 g of N-[2-hydroxy-1-(4-methyl-piperazin-1-ylmethyl)ethyl] acetamide in 10.3 mL of an aqueous acid solution of 6N hydrochloric acid is heated at a temperature of about 100° C. for 3 hours. After cooling at a temperature of about 60° C., the reaction medium is filtered and the filtrate is concentrated under reduced pressure (2 kPa) at a temperature of about 60° C. About 1 g of 2-amino-3-(4-methyl-piperazinyl)-1-propanol, hydrochloride is obtained in the form of a tacky beige-colored paste. [Infrared spectrum (KBr) 3337; 2955; 2637; 2522; 1617; 1457; 1062; 1009 and 962 cm−1].

Quelle