Reaktion #75502

Reaktionsgleichung

Compound 1

2-fluoro-5H-dibenzo[a,d]cycloheptene

hydrochloric acid

HCl 2-propanol

→

(±)-(2α,3aβ,12bα)-11-fluoro-3,3a,8,12b-tetrahydro-N, N-dimethyl-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan-2-methanamine hydrochloride

Ausbeute 43.0%

3-fluoro-6,10b-dihydro-1aH-dibenzo-[3,4:6,7]cyclohept[1,2-b]oxirene

Ausbeute 43.0%

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated
2. 2
   SonstigeThe residue was triturated under boiling 2-propanone
3. 3
   Filtrationfiltered off
4. 4
   Sonstigedried

Vorschrift

Compound 1 was dissolved in diethyl ether (20 ml) and converted into the hydrochloric acid salt (1:1) by dropwise addition of 6 N HCl/2-propanol. The solvent was evaporated. The residue was triturated under boiling 2-propanone, filtered off and dried, yielding 2.17 g (43%) of (±)-(2α,3aβ,12bα)-11-fluoro-3,3a,8,12b-tetrahydro-N, N-dimethyl-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan-2-methanamine hydrochloride (compound 2; mp. 239.1° C.).

Quelle