Reaktion #75495

Reaktionsgleichung

ethyl 2-amino-2-(4-trifluormethyl-3-pyridinecarbonyloxyimino)-acetate

diethyl ether

→

3-Ethoxycarbonyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

Lösungsmittel

—

mixture

xylene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefor 6 h
2. 2
   Temperaturthe mixture is cooled
3. 3
   FiltrationThe mixture is filtered with suction through a glass
4. 4
   Filtrationfilter frit
5. 5
   Einengenthe solution is then concentrated

Vorschrift

20 g of ethyl 2-amino-2-(4-trifluormethyl-3-pyridinecarbonyloxyimino)-acetate are dissolved in 200 ml of a mixture of xylene and toluene and admixed with 5 g of Amberlyst 15. The mixture is boiled at 125-130° C. for 6 h using a Dean-Stark apparatus. After the reaction has ended, the mixture is cooled and admixed with a small amount of diethyl ether. The mixture is filtered with suction through a glass filter frit, and the solution is then concentrated. This gives 15.8 g of the product as a yellow oil.

Quelle