Reaktion #75411

Reaktionsgleichung

1-[3-(acetylthio)-2-(methylthiomethyl)propanoyl]-L-proline

→

[3-mercapto-2-(methylthiomethyl)propanoyl]-L-proline

Lösungsmittel

water

ammonia

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter twenty minutes
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   SonstigeThe organic layer is dried
4. 4
   Einengenconcentrated to dryness

Vorschrift

1-[3-(acetylthio)-2-(methylthiomethyl)propanoyl]-L-proline (1.2 g.) is dissolved in a mixture of water (12 ml.) and concentrated ammonia (12 ml.) under a blanket of argon. After twenty minutes, the reaction mixture is acidified and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness to yield 1-([3-mercapto-2-(methylthiomethyl)propanoyl]-L-proline.

Quelle