Reaktion #75395

Reaktionsgleichung

7,7-dimethyl-2-phenethyl-5-(2-chloro-ethyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

2-(3,4-dimethoxy-phenyl)-ethylamine

→

7,7-Dimethyl-2-phenethyl-5-[2-(2-(3,4-dimethoxy-phenyl)ethylamino)-ethyl]-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione dihydrochloride

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Extraktionextracted with water
3. 3
   SonstigeThe organic phase was evaporated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in acetone
5. 5
   SonstigeThe dihycrochloride was precipitated from the acetone solution with ethereal hydrochloric acid

Vorschrift

2.8 gm of 7,7-dimethyl-2-phenethyl-5-(2-chloro-ethyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione were heated at 150° C. for 40 minutes with 5 ml of 2-(3,4-dimethoxy-phenyl)-ethylamine. After cooling, the mixture was dissolved in ether, and the solution was several times extracted with water weakly acidified with acetic acid. The organic phase was evaporated, and the residue was dissolved in acetone. The dihycrochloride was precipitated from the acetone solution with ethereal hydrochloric acid.

Quelle