Reaktion #75389

Reaktionsgleichung

7,7-dimethyl-2-(2-methoxy-5-metylmercapto-phenyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

hydrogen peroxide

potassium carbonate

→

crude product

7,7-Dimethyl-2-(2-methoxy-5-methylsulfinyl-phenyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

Lösungsmittel

acetic acid

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with chloroform

Vorschrift

3.0 gm of 7,7-dimethyl-2-(2-methoxy-5-metylmercapto-phenyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione were dissolved in 60 ml of glacial acetic acid and then 0.88 ml of 30% hydrogen peroxide were slowly added dropwise at room temperature. After stirring for 30 minutes, the solution was neutralized with an aqueous saturated potassium carbonate solution, diluted with water and extracted with chloroform. The residual crude product obtained after evaporation of the chloroform was purified on a silicagel column (eluant: chloroform with increasing content of acetone).

Quelle