Reaktion #75386

ord-4924df22b6b444dcb4a340a120e8213e

Reaktionsgleichung

CC(=O)Nc1ccc2c(c1[N+](=O)[O-])C(=O)NC(=O)C2(C)C
4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione
O=C([O-])O.[Na+]
sodium bicarbonate
→
CCC(=O)Nc1ccc2c(c1[N+](=O)[O-])C(=O)NC(=O)C2(C)C
4,4-Dimethyl-7-propionylamino-8-nitro-2H,4H-isoquinoline-1,3-dione

Edukte

CC(=O)Nc1ccc2c(c1[N+](=O)[O-])C(=O)NC(=O)C2(C)C
4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione
—
ice water
O=C([O-])O.[Na+]
sodium bicarbonate

Reagenzien

Keine

Lösungsmittel

CCC(=O)OC(=O)CC
propionic acid anhydride

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe obtained precipitate was purified on a silicagel column (eluant: chloroform/acetone 19:1)

Vorschrift

29.1 gm of 4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione were refluxed for 4 hours with 50 ml of propionic acid anhydride. The mixture was then poured into ice water and neutralized with sodium bicarbonate. The obtained precipitate was purified on a silicagel column (eluant: chloroform/acetone 19:1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04176184uspto-grants-1979_11