Reaktion #75382

Reaktionsgleichung

4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione

benzoyl chloride

→

4,4-dimethyl-7-benzoylamino-8-nitro-2H,4H-isoquinoline-1,3-dione

Ausbeute 68.0%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 10 hours
2. 2
   TemperaturAfter cooling
3. 3
   Filtrationthe reaction mixture was suction-filtered
4. 4
   Waschenthe filter cake was washed with toluene and petroleum ether

Vorschrift

43.8 gm of 4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione were admixed with 200 gm of xylene with 104 gm of benzoyl chloride, and the mixture was refluxed for 10 hours while stirring. After cooling, the reaction mixture was suction-filtered, and the filter cake was washed with toluene and petroleum ether, yielding 36 gm (68% of theory) of 4,4-dimethyl-7-benzoylamino-8-nitro-2H,4H-isoquinoline-1,3-dione, m.p. above 270° C.

Quelle