Reaktion #75373

Reaktionsgleichung

3-sulphamoyl-4-phenoxy-5-amino-benzoic acid

2,5-dimethoxy-tetrahydrofurane

→

3-Sulphamoyl-4-phenoxy-5-[1-pyrrolyl]-benzoic acid

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated to dryness in vacuo
2. 2
   Sonstigethe residue is recrystallised from ethyl acetate

Vorschrift

A mixture of 3-sulphamoyl-4-phenoxy-5-amino-benzoic acid (3.08 g=10 mmols); P. W. Feit, J. Med. Chem. 14,432 (1971), 2,5-dimethoxy-tetrahydrofurane (1.32 g=10 mmols) and 5 ml of glacial acetic acid is refluxed for 15 minutes in an oil bath and evaporated to dryness in vacuo and the residue is recrystallised from ethyl acetate; the compound melts at 209°-210° C.

Quelle