Reaktion #75338

Reaktionsgleichung

2-aminonicotinaldehyde

ethyl α-cyanoacetate

piperidine

→

2-Hydroxy-3-cyano-1,8-naphthyridine

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux
2. 2
   Temperaturthe solution is cooled to 0°-4° C
3. 3
   FiltrationThe yellow solid is filtered
4. 4
   Sonstigedried
5. 5
   Sonstigeto yield 2.5 g

Vorschrift

A mixture of 2-aminonicotinaldehyde (2.44 g., 0.02 m), ethyl α-cyanoacetate (4.52 g., 0.04 m.), absolute ethanol (50 ml.) and piperidine (0.5 ml) is stirred under reflux. After 1 hour, the solution is cooled to 0°-4° C. The yellow solid is filtered and dried to yield 2.5 g. (73%) of 2-hydroxy-3-cyano-1,8-naphthyridines, m.p. 300° C.

Quelle