Reaktion #7533

Reaktionsgleichung

1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-azetidinol

hydrogen chloride-ethyl acetate

→

1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-azetidinol hydrochloride

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat 5° C. for 1 hour
2. 2
   SonstigeThe crystals precipitated
3. 3
   Filtrationwere collected by filtration
4. 4
   Waschenwashed with ethyl acetate
5. 5
   Sonstigedried

Vorschrift

In 4.2 mL of ethyl acetate was dissolved 1.03 g of 1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-azetidinol, and to the solution was added 0.86 mL of a 4.76 mol/L dried hydrogen chloride-ethyl acetate solution. The resulting mixture was stirred at room temperature for 1 hour and then at 5° C. for 1 hour. The crystals precipitated were collected by filtration, washed with ethyl acetate and then dried to obtain 0.98 g of 1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-azetidinol hydrochloride.

Quelle