Reaktion #75314

ord-5913794543be446eb95831839908c1b9

Reaktionsgleichung

CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N[N+](=O)[O-])C(=O)OCc1ccccc1
Boc-Ile-Ala-Gly-Gln-D-Arg(NO2)-OBzl
CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)O
Boc-Gln-Gly-OH
→
CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N[N+](=O)[O-])C(=O)OCc1ccccc1
Boc-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg(NO2)-OBzl

Edukte

CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N[N+](=O)[O-])C(=O)OCc1ccccc1
Boc-Ile-Ala-Gly-Gln-D-Arg(NO2)-OBzl
CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)O
Boc-Gln-Gly-OH

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Boc-Ile-Ala-Gly-Gln-D-Arg(NO2)-OBzl (3.2 g, 5 m mol) was demasked with respect to the N-masking group, and coupled with Boc-Gln-Gly-OH (1.7 g, 5.5 m mol) in the manner similar to that of Example 1, paragraph 7).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04176009uspto-grants-1979_11