Reaktion #75258

Reaktionsgleichung

4-(4-acetyl-8-hydroxytridecyl)benzoic acid

acetic anhydride

→

crude product

4-(4-Acetyl-8-acetoxytridecyl)benzoic Acid

Lösungsmittel

ethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is then cooled
2. 2
   workup.DISSOLUTIONdissolved in 80 ml
3. 3
   ExtraktionThe solution is extracted with an ice-cold solution of 8 g
4. 4
   SonstigeThe basic solution is separated
5. 5
   Waschenwashed with water
6. 6
   Trocknendried over sodium sulfate
7. 7
   SonstigeThe ether is evaporated

Vorschrift

A mixture of 4-(4-acetyl-8-hydroxytridecyl)benzoic acid (9.0 g., 0.025 mole) and acetic anhydride (6.1 g., 0.06 mole) is heated at 60° C. for 18 hours. The mixture is then cooled and dissolved in 80 ml. ethyl ether. The solution is extracted with an ice-cold solution of 8 g. sodium hydroxide in 150 ml. water. The basic solution is separated and acidified with concentrated hydrochloric acid. The oily acid which separates is taken up in ether, washed with water, and dried over sodium sulfate. The ether is evaporated to leave the oily crude product.

Quelle