Reaktion #7513

Reaktionsgleichung

ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate

phosphorus oxychloride

→

title compound

ethyl 4-chloro-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated under reduced pressure
2. 2
   workup.DISSOLUTIONThe obtained residue was dissolved in ethyl acetate
3. 3
   Waschenwashed with saturated aqueous sodium hydrogencarbonate solution (×3) and saturated brine (×1)
4. 4
   Trocknendried over anhydrous sodium sulfate
5. 5
   EinengenThe solvent was concentrated under reduced pressure

Vorschrift

To ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate (2.85 g, 10 mmol) was added phosphorus oxychloride (10 mL, 2 mmol) and the mixture was stirred at 120° C. for 15 h. The reaction mixture was concentrated under reduced pressure. The obtained residue was dissolved in ethyl acetate, washed with saturated aqueous sodium hydrogencarbonate solution (×3) and saturated brine (×1) and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure to give the title compound (2.9 g, 100%).

Quelle