Reaktion #75128

Reaktionsgleichung

hydrogen

3-[(4,5-dichloro-2-nitrophenyl)amino]-1-propanol

→

3-[(2-amino-4,5-dichlorophenyl)amino]-1-propanol hydrochloride

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe catalyst is filtered off
2. 2
   SonstigeThe solvent is evaporated
3. 3
   workup.STIRRINGthe solid residue is stirred in 2-propanol
4. 4
   FiltrationThe product is filtered off
5. 5
   Sonstigedried in vacuo

Vorschrift

A mixture of 39.7 parts of 3-[(4,5-dichloro-2-nitrophenyl)amino]-1-propanol and 400 parts of methanol is hydrogenated at normal pressure and at room temperature with 5 parts of Raney-nickel catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off. The filtrate is acidified with 24 parts of a hydrochloric acid solution while stirring. The solvent is evaporated and the solid residue is stirred in 2-propanol. The product is filtered off and dried in vacuo, yielding 31.5 parts of 3-[(2-amino-4,5-dichlorophenyl)amino]-1-propanol hydrochloride; mp. 185° C.

Quelle