Reaktion #75091

Reaktionsgleichung

3-tert. butyl-4-phenyl isocarbostyril

phosphorous oxychloride

→

3-tert.butyl-1-chloro-4-phenyl isoquinoline

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 11 g
2. 2
   SonstigeThe excess solvent is removed in vacuo and ice
3. 3
   workup.ADDITIONis added to the residue
4. 4
   FiltrationThe resulting solid is filtered
5. 5
   Waschenwashed with water
6. 6
   Sonstigerecrystallized from ethanol

Vorschrift

A mixture of 11 g. (0.04 mole) of 3-tert. butyl-4-phenyl isocarbostyril and 40 ml. of phosphorous oxychloride is refluxed for one hour. The excess solvent is removed in vacuo and ice is added to the residue and stirred. The resulting solid is filtered and washed with water and recrystallized from ethanol to give 3-tert.butyl-1-chloro-4-phenyl isoquinoline; m.p. 139°-140° C.

Quelle