Reaktion #75057

Reaktionsgleichung

potassium hydroxide

1-acetoxy-2-(4-phenoxyphenoxy)-cyclopentane

→

2-(4-phenoxyphenoxy)-cyclopentan-1-ol

Lösungsmittel

water

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is then refluxed for 3 hours
2. 2
   Temperaturafter cooling
3. 3
   Einengenconcentrated to 166 of its original volume by rotary evaporation
4. 4
   workup.ADDITIONThe residue is poured into ice-water
5. 5
   ExtraktionAfter extraction with ether
6. 6
   Waschenthe organic phase is washed three times with saturated sodium chloride solution
7. 7
   Trocknendried over sodium sulphate
8. 8
   Einengenconcentrated by rotary evaporation
9. 9
   workup.DISTILLATIONDistillation of the residue

Vorschrift

A solution of 1.68 g of potassium hydroxide in 20 ml of water is added at room temperature to a solution of 6.24 g of 1-acetoxy-2-(4-phenoxyphenoxy)-cyclopentane in 50 ml of ethanol. The mixture is then refluxed for 3 hours and, after cooling, concentrated to 166 of its original volume by rotary evaporation. The residue is poured into ice-water. After extraction with ether, the organic phase is washed three times with saturated sodium chloride solution, dried over sodium sulphate and concentrated by rotary evaporation. Distillation of the residue yields 2-(4-phenoxyphenoxy)-cyclopentan-1-ol as a colourless oil with a boiling point of 181°-185° C./0.001 torr.

Quelle