Reaktion #75033

Reaktionsgleichung

2-butylamino-4-methyloxazole

ethyl isocyanate

→

1-Butyl-3-ethyl-1-(4-methyl-2-oxazolyl)urea

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 2 hours
2. 2
   Sonstigeevaporated to dryness
3. 3
   workup.DISSOLUTIONThe residual oil was dissolved in ether
4. 4
   Waschenthe solution was washed with 2N HCl
5. 5
   Sonstigedried
6. 6
   Sonstigeevaporated
7. 7
   workup.DISTILLATIONThe residue was distilled under vacuum b.p. 128° C./1.0 mm

Vorschrift

A solution of 2-butylamino-4-methyloxazole (15.0 g, 0.0972 mol) and ethyl isocyanate (7.6 g, 0.107 mol) in dry benzene was heated under reflux for 2 hours and then evaporated to dryness. The residual oil was dissolved in ether and the solution was washed with 2N HCl, dried and evaporated. The residue was distilled under vacuum b.p. 128° C./1.0 mm. IR 3275, 1696, 1590 cm-1.

Quelle