Reaktion #75032

Reaktionsgleichung

Potassium tetrachloroplatinite

1,2-diaminocyclohexane

→

Dichloro (1,2-diaminocyclohexane)platinum (II)

Ausbeute 90.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe insoluble product was removed by filtration
2. 2
   Waschenwashed with water
3. 3
   Trocknenwith methanol, and oven-dried
4. 4
   SonstigeThe product was then purified by dissolution in dimethylformamide
5. 5
   Filtrationfiltration, and addition of three volumes of methanol or 0.1 N HCl
6. 6
   FiltrationThis product was filtered
7. 7
   Waschenwashed
8. 8
   Sonstigedried as above
9. 9
   SonstigeThe yield in purification

Vorschrift

Dichloro (1,2-diaminocyclohexane)platinum (II) was synthesized as described by Gale et al, Research Communications in Chemical Pathology and Pharmacology, Volume 7, No. 3, Pages 529-538, March 1974. Thus, Potassium tetrachloroplatinite, K2Pt Cl4 (20 mM) in 75 ml water was mixed with 1,2-diaminocyclohexane (20 mM) for three hours at room temperature. The insoluble product was removed by filtration, washed with water and then with methanol, and oven-dried. The yield was approximately 90% of theory. The product was then purified by dissolution in dimethylformamide, filtration, and addition of three volumes of methanol or 0.1 N HCl. This product was filtered, washed, and dried as above. The yield in purification was 47%.

Quelle