Reaktion #75000

Reaktionsgleichung

2-bromo-4-nitrophenylhydrazine

ethyldiisopropylamine

pivaloyl chloride

→

product

Ausbeute 60.7%

Pivalic acid 2-(2-bromo-4-nitrophenyl)hydrazide

Ausbeute 60.7%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturchilled (0°) solution
2. 2
   workup.STIRRINGThe reaction mixture was stirred at ambient temperature for 1 hour
3. 3
   Einengenconcentrated to dryness under reduced pressure
4. 4
   workup.ADDITIONThe residue was treated with water
5. 5
   Filtrationfiltered
6. 6
   Sonstigerecrystallized from ethanol

Vorschrift

To a stirred and chilled (0°) solution containing 200 g (0.86 mol) of 2-bromo-4-nitrophenylhydrazine (m.p. 143°-145°) and 116.8 g (0.9 mol) of ethyldiisopropylamine in 1000 ml of tetrahydrofuran was added dropwise 108.5 g (0.9 mol) of pivaloyl chloride. The reaction mixture was stirred at ambient temperature for 1 hour and then concentrated to dryness under reduced pressure. The residue was treated with water, filtered and recrystallized from ethanol to give 165 g (52%) of product as a light yellow solid; m.p. 145° C.

Quelle