Reaktion #7497

Reaktionsgleichung

sodium hydride

ethyl 7-oxo-4-azepanecarboxylate

tert-butyl 2-bromobutanoate

→

diester

Ausbeute 94.4%

ethyl 1-[1-(tert-butoxycarbonyl)propyl]-7-oxo-4-azepanecarboxylate

Ausbeute 94.4%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwith reflux condenser, magnetic stirrer
2. 2
   Einengenconcentrated to dryness
3. 3
   workup.ADDITIONthe residue was poured on ice/water and neutralised with solid ammonium chloride
4. 4
   ExtraktionThe mixture was extracted three times with CH2Cl2
5. 5
   Trocknenthe combined organic phases were dried over magnesium sulfate
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated to dryness
8. 8
   SonstigeThe residue was purified by PrepLC (1 kg SiO2, CH2Cl2/MTBE, 85/15)

Vorschrift

In a 150 ml three necked flask fitted with reflux condenser, magnetic stirrer and dropping funnel under inert atmosphere, 5.09 g (27.5 mmoles, 1 eq) of ethyl 7-oxo-4-azepanecarboxylate 28 and 12.27 g (55 mmoles, 2 eq) of tert-butyl 2-bromobutanoate were dissolved in 70 ml of acetonitrile. The temperature was raised to 50° C. and 1.32 g (55 mmoles, 2 eq) of sodium hydride were added portionwise (exothermic). The mixture was stirred one more hour at 50° C. and concentrated to dryness, the residue was poured on ice/water and neutralised with solid ammonium chloride. The mixture was extracted three times with CH2Cl2, the combined organic phases were dried over magnesium sulfate, filtered and concentrated to dryness. The residue was purified by PrepLC (1 kg SiO2, CH2Cl2/MTBE, 85/15) to give 8.5 g of pure diester 29, 69% yield.

Quelle