Reaktion #74902

Reaktionsgleichung

potassium carbonate

3,4-methylenedioxyphenol

α-bromoacetophenone

sodium carbonate

→

α-(3,4-methylenedioxyphenoxy)acetophenone

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 25 g
2. 2
   Temperaturreflux temperature
3. 3
   Temperaturmaintained
4. 4
   Temperaturat reflux for 16 hours
5. 5
   workup.ADDITIONTo the mixture is added 50 g
6. 6
   Sonstigewhile collecting water in a Barrett water trap
7. 7
   workup.ADDITIONThe mixture is then diluted with a mixture of water and benzene
8. 8
   WaschenThe benzene layer is washed with water
9. 9
   SonstigeIt is collected
10. 10
    Waschenrinsed with benzene
11. 11
    Sonstigedried
12. 12
    Sonstigeto provide a white powder which
13. 13
    Sonstigeis recrystallized from ethanol

Vorschrift

A mixture of 25 g. (0.181 mole) of 3,4-methylenedioxyphenol, 36 g. (0.181 mole) of α-bromoacetophenone and 41.2 g. (0.40 mole) of sodium carbonate in 350 ml. of benzene is heated to its reflux temperature and maintained at reflux for 16 hours. To the mixture is added 50 g. of potassium carbonate, and the mixture is refluxed for an additional 7 days while collecting water in a Barrett water trap. The mixture is then diluted with a mixture of water and benzene. The benzene layer is washed with water, then cold 5 percent sodium hydroxide solution. A precipitate forms in the benzene layer. It is collected, rinsed with benzene and dried to provide a white powder which is recrystallized from ethanol to provide α-(3,4-methylenedioxyphenoxy)acetophenone, m.p. 123°-126° C.

Quelle