Reaktion #748455

Reaktionsgleichung

oxadiazole

{3-(3-Chloro-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone

oxetan-3-amine

→

Morpholin-4-yl{3-[3-(oxetan-3-ylamino)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]-piperidin-1-yl}methanone

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed under reduced pressure
2. 2
   Sonstigethe crude product was purified by means of preparative HPLC

Vorschrift

To a solution of 100 mg (0.225 mmol) of the oxadiazole from Example 23A in 1.5 ml of ethanol were added 335 mg (4.50 mmol) of oxetan-3-amine, and then the reaction mixture was stirred at 80 for 3 days. The solvent was removed under reduced pressure and the crude product was purified by means of preparative HPLC. Yield: 59.7 mg (55% of theory)

Quelle