Reaktion #74791

Reaktionsgleichung

diborane

[9-methoxy-2-oxo-3,4,5,5a,6,7-hexahydro-2H-naphth-[1,2-d]azepin-1-yl]-N-isopropyl-acetamide

hydrochloric acid

→

1-(2-isopropylaminoethyl)-3,4,5,5a,6,7-hexahydro-9-methoxy-2H-naphth[1,2-d]azepin-2-one

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is refluxed for one hour
2. 2
   workup.DISTILLATIONThe tetrahydrofuran is distilled off under reduced pressure
3. 3
   workup.ADDITIONthe remainder is diluted with water
4. 4
   FiltrationThe resulting precipitate is filtered off
5. 5
   Extraktionre-extracted with hot water
6. 6
   WaschenThe aqueous filtrate is washed with diethyl ether
7. 7
   ExtraktionThe suspension is extracted with methylene chloride
8. 8
   Sonstigethe extract dried
9. 9
   Sonstigeevaporated
10. 10
    Sonstigethe residue recrystallized from acetone

Vorschrift

80 ml of 1 M diborane in tetrahydrofuran are added to the suspension of 6.8 g of [9-methoxy-2-oxo-3,4,5,5a,6,7-hexahydro-2H-naphth-[1,2-d]azepin-1-yl]-N-isopropyl-acetamide in 100 ml of tetrahydrofuran while stirring under nitrogen at 0°. After 20 hours 60 ml of 3 N hydrochloric acid are added dropwise and the mixture is refluxed for one hour. The tetrahydrofuran is distilled off under reduced pressure and the remainder is diluted with water. The resulting precipitate is filtered off and re-extracted with hot water. The aqueous filtrate is washed with diethyl ether and basified with 3 N aqueous sodium hydroxide. The suspension is extracted with methylene chloride, the extract dried, evaporated and the residue recrystallized from acetone, to yield the 1-(2-isopropylaminoethyl)-3,4,5,5a,6,7-hexahydro-9-methoxy-2H-naphth[1,2-d]azepin-2-one melting at 147°-149°.

Quelle