Reaktion #74782

Reaktionsgleichung

2-(3-hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine

dimethyl sulfate

→

2-(3-hydroxy-1,2,3,4-tetrahydronaphthalenyl)-1-methyl piperidine

Lösungsmittel

HOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter several hours

Vorschrift

The 2-(3-hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine thus obtained is quaternized with dimethyl sulfate on the steam bath neat. After several hours, the salt is dissolved in HOAc and reduced over a mixture of PtO2 and Pd/C to yield 2-(3-hydroxy-1,2,3,4-tetrahydronaphthalenyl)-1-methyl piperidine.

Quelle