Reaktion #746922

Reaktionsgleichung

N-(5-Amino-2-methyl-phenyl)-acetamide

NaH

4-(2-Chloro-oxazol-5-yl)-benzonitrile

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title compound

Ausbeute 75.0%

4-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzo-nitrile

Ausbeute 75.0%

Lösungsmittel

DMF

DMF

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to 0° C
2. 2
   workup.WAITAfter 30 min.
3. 3
   FiltrationThe solid was collected by filtration
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried under vacuum

Vorschrift

A solution of N-(5-Amino-2-methyl-phenyl)-acetamide (1.1 g, 6.7 mmol) in DMF (20 mL) was added to a suspension of NaH (402 mg, 10.05 mmol, 60% dispersion in mineral oil) in DMF (20 mL) at 0° C. under an atmosphere of argon. The mixture was stirred for 30 min. at room temperature and cooled to 0° C. A solution of 4-(2-Chloro-oxazol-5-yl)-benzonitrile (1.37 g, 6.7 mmol) in DMF (20 mL) was added dropwise to the mixture. After 30 min., at 0° C., the reaction was poured into ice water (200 mL). The solid was collected by filtration, washed with water, and dried under vacuum to afford the title compound (1.45 g, 75%). m.p.=228° C.

Quelle