Reaktion #746812

Reaktionsgleichung

EtOAc

cyclohexanone

acetic acid

1-(4-bromophenyl)hydrazine hydrochloride

→

1-(4-bromophenyl)-2-cyclohexylidenehydrazine

Ausbeute 92.0%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturUpon completion, the reaction mixture was cooled down to room temperature
2. 2
   Filtrationfiltered off

Vorschrift

A 250-mL round-bottomed flask was charged with 1-(4-bromophenyl)hydrazine hydrochloride (10 g, 45.05 mmol, 1.00 equiv) in EtOH (120 mL). To this was added cyclohexanone (8.8 g, 89.80 mmol, 2.00 equiv) and acetic acid (2.7 g, 45.00 mmol, 1.00 equiv). The resulting mixture was heated to 105° C. in an oil bath for about 1 hour. The reaction progress was monitored by TLC (EtOAc:PE=1:1). Upon completion, the reaction mixture was cooled down to room temperature and filtered off to obtain 1-(4-bromophenyl)-2-cyclohexylidenehydrazine as a yellow solid (11 g, 92%).

Quelle