Reaktion #74634

Reaktionsgleichung

tert-butyl 2-[1-(diphenylmethyl)azetidin-3-yl]hydrazinecarboxylate

hydrogen chloride

→

title compound

Ausbeute 85.0%

1-(diphenylmethyl)-3-hydrazinoazetidine dihydrochloride

Ausbeute 85.0%

Lösungsmittel

1,4-dioxane

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThen the reaction mixture was concentrated in vacuo
2. 2
   Sonstigethe residue was triturated with diethyl ether

Vorschrift

To a stirred suspension of tert-butyl 2-[1-(diphenylmethyl)azetidin-3-yl]hydrazinecarboxylate (Preparation 691, 19.3 g, 54.6 mmol) in 1,4-dioxane (64 ml) was added 4M hydrogen chloride in 1,4-dioxane (290 ml) at 0° C. and stirred at room temperature for 4 hours. Then the reaction mixture was concentrated in vacuo and the residue was triturated with diethyl ether to give 15 g (85%) of the title compound as a white solid.

Quelle