Reaktion #74568

Reaktionsgleichung

2-aminothiazole

pyridine

2,4-difluorobenzenesulfonyl chloride

→

2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide

Lösungsmittel

methylene chloride

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenwas concentrated
2. 2
   Sonstigepurified by flash column chromatography
3. 3
   Wascheneluting with hexane/ethyl acetate

Vorschrift

To a slurry of 2-aminothiazole (15.08 g, 0.1506 mol) in methylene chloride (100 mL) and pyridine (24 mL, 0.30 mol) was added dropwise over 20 minutes a solution of 2,4-difluorobenzenesulfonyl chloride (10 mL, 0.07 mol) in 10 mL of methylene chloride. After stirring at room temperature for 48 hours the reaction was concentrated and purified by flash column chromatography eluting with hexane/ethyl acetate. LCMS Rt=1.21 minutes MS m/z 277 [MH]+

Quelle