Reaktion #74567

Reaktionsgleichung

2-aminothiazole

pyridine

3,4-difluorobenzenesulphonyl chloride

→

3,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide

Lösungsmittel

methylene chloride

methylene chloride

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with 1N HCl
2. 2
   TrocknenThe organic layer was dried over sodium sulfate
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated
5. 5
   SonstigeThe residue was purified by flash column chromatography

Vorschrift

To a slurry of 2-aminothiazole (23.88 g, 0.2384 mol) in methylene chloride (150 mL) and pyridine (38.0 mL, 0.470 mol) was added dropwise a solution of 3,4-difluorobenzenesulphonyl chloride (25.0 g, 0.118 mol) in 10 mL of methylene chloride. After stirring for 48 hours the reaction was diluted with more dichloromethane and extracted with 1N HCl. The organic layer was dried over sodium sulfate, filtered, and concentrated. The residue was purified by flash column chromatography to give 3,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide as a white solid. LCMS Rt=1.24 minutes MS m/z 277 [MH]+

Quelle