Reaktion #745262

Reaktionsgleichung

sodium hydroxide

Cyclohexanecarboxaldehyde

diethylamine hydrochloride

acetic acid

→

cyclohexylmethyl-ethyl-amine

Ausbeute 83.8%

Lösungsmittel

methylene chloride

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe mixture is separated
2. 2
   Waschenthe organic layer is washed with a saturated brine
3. 3
   Trocknendried over magnesium sulfate
4. 4
   Einengenthe mixture is concentrated under reduced pressure

Vorschrift

Cyclohexanecarboxaldehyde (38 g), diethylamine hydrochloride (55 g) and acetic acid (29 ml) are dissolved in methylene chloride (500 ml) and thereto is added triacetoxy sodium borohydride (71.8 g) at room temperature and the mixture is stirred at room temperature overnight. To the reaction solution are added a 2N-aqueous sodium hydroxide solution and methylene chloride, and the mixture is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate, and the mixture is concentrated under reduced pressure to give cyclohexylmethyl-ethyl-amine (40.1 g) as a crude product. MS (m/z): 142 [M+H]+

Quelle