Reaktion #745153

Reaktionsgleichung

1-(3-tert-butyl-5-hydroxy-4-methoxyphenyl)ethanone

2-(2-bromoethoxy)tetrahydropyran

→

title compound

Ausbeute 84.7%

1-{3-tert-Butyl-4-methoxy-5-[2-(tetrahydropyran-2-yloxy)ethoxy]phenyl}ethanone

Ausbeute 84.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeHowever, the crude product was purified
2. 2
   Sonstigesilica gel (40 g cartridge, n-heptane/EA gradient of 0-50% within 60 min)

Vorschrift

Analogously to O2.071, 1-(3-tert-butyl-5-hydroxy-4-methoxyphenyl)ethanone (O3.070; 5.0 g) was reacted with 2-(2-bromoethoxy)tetrahydropyran (5.64 g). However, the crude product was purified using silica gel (40 g cartridge, n-heptane/EA gradient of 0-50% within 60 min). 6.68 g of the title compound were obtained.

Quelle