Reaktion #74507

Reaktionsgleichung

5-bromo-2-chloro-4-methoxybenzonitrile

NaOH

EtOH

→

title compound

5-Bromo-2-chloro-4-methoxybenzoic acid

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed overnight
2. 2
   SonstigeEtOH was removed under reduced pressure
3. 3
   workup.ADDITIONThe mixture was diluted with water and neutralized with hydrochloric acid (3.0 N)
4. 4
   FiltrationThe resulting solid was filtered
5. 5
   Sonstigedried in vacuo

Vorschrift

A mixture of 5-bromo-2-chloro-4-methoxybenzonitrile (30.7 g, 124 mmol) and NaOH (127 g, 3.11 mol) in EtOH (500 mL) and water (250 mL) was refluxed overnight. After cooling to room temperature, EtOH was removed under reduced pressure. The mixture was diluted with water and neutralized with hydrochloric acid (3.0 N). The resulting solid was filtered and dried in vacuo to give title compound (32.9 g, quantitative) as a white solid.

Quelle