Reaktion #74503

Reaktionsgleichung

water

2,4-dichlorobenzoic acid

compound 80

2,4-dichlorobenzoic acid

bromine

→

title compound

Ausbeute 187.5%

5-Bromo-2,4-dichlorobenzoic acid

Ausbeute 187.5%

Lösungsmittel

chlorosulfonic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to ambient temperature
2. 2
   SonstigeThe resulting solid was isolated by filtration
3. 3
   Sonstigedried in vacuo

Vorschrift

To a solution of 2,4-dichlorobenzoic acid (compound 80, 25.0 g, 131 mmol) in chlorosulfonic acid (100 mL) was added bromine (3.4 mL, 65 mmol) and sulfur (0.20 g, 6.6 mmol). The reaction mixture was stirred at 70° C. overnight and then cooled to ambient temperature. The reaction mixture was poured into iced water. The resulting solid was isolated by filtration and dried in vacuo to yield title compound (32.9 g, 93%) as pale brown solid.

Quelle