Reaktion #74495

Reaktionsgleichung

Bromine

1-hydroxy-2-naphthoic acid

compound 66

1-hydroxy-2-naphthoic acid

→

title compound

Ausbeute 92.1%

4-Bromo-1-hydroxy-2-naphthoic acid

Ausbeute 92.1%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting solid was filtered
2. 2
   Sonstigedried in vacuo

Vorschrift

Bromine (6.1 mL, 120 mmol) was added to a solution of 1-hydroxy-2-naphthoic acid (compound 66, 18.9 g, 100 mmol) in glacial acetic acid (250 mL). The mixture was stirred at room temperature overnight. The resulting solid was filtered and dried in vacuo to yield the title compound (24.6 g, 92%) as a white solid.

Quelle