Reaktion #74448

Reaktionsgleichung

HCl

tert-butyl {[5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindol-5-yl]methyl}carbamate

HCl

→

title compound

5-(aminomethyl)-5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindol-1-ium Chloride

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITcontinued for another 3 h
3. 3
   EinengenThe reaction mixture was then concentrated (
4. 4
   Sonstigeazeotroped once from toluene) and
5. 5
   Sonstigedried under vacuum

Vorschrift

To a solution of tert-butyl {[5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindol-5-yl]methyl}carbamate (575 mg) in dioxane (2 mL) was added a HCl solution (3.265 mL, 4 M in dioxane) and stirred at room temperature for 1.5 h. After this time 1.5 mL more HCl solution was added and stirring continued for another 3 h. The reaction mixture was then concentrated (azeotroped once from toluene) and dried under vacuum to give title compound as a white solid. Mass. found (M+H)+, 342.0.

Quelle