Reaktion #744149

Reaktionsgleichung

furo[2,3-c]pyridin-5-ylmethyl acetate

sodium hydroxide

→

oil

Ausbeute 70.2%

Furo[2,3-c]pyridin-5-ylmethanol

Ausbeute 70.2%

Lösungsmittel

1,4-dioxane

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was then partitioned between ethyl acetate and water
2. 2
   SonstigeThe organic fractions were separated
3. 3
   Sonstigedried
4. 4
   Sonstigethen evaporated to dryness

Vorschrift

A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18 h. The mixture was then partitioned between ethyl acetate and water. The organic fractions were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70%).

Quelle