Reaktion #743614

Reaktionsgleichung

5-tert-Butyl-2,3-dihydro-1H-inden-1-ylamine

N-acetyl-(L)-leucine

→

title compound

(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-ylamine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool to ambient temperature
2. 2
   FiltrationThe solids were filtered
3. 3
   Waschenwashed with toluene
4. 4
   Temperaturto reflux
5. 5
   Temperaturto cool to ambient temperature
6. 6
   Filtrationthe solids were filtered
7. 7
   SonstigeThe solid was dried at 40° C. under reduced pressure

Vorschrift

5-tert-Butyl-2,3-dihydro-1H-inden-1-ylamine (25.51 g, 93% potency), N-acetyl-(L)-leucine (23.34 g), and methanol (315 mL) were combined and heated at 65° C. for 1 hour. The solution was allowed to cool to ambient temperature. The solids were filtered and washed with toluene. The solid was then resuspended in methanol (125 mL) and brought to reflux. The solution was allowed to cool to ambient temperature and the solids were filtered. The solid was dried at 40° C. under reduced pressure to provide the title compound (98.7% ee).

Quelle