Reaktion #74353

ord-7fea2beba6ac4b89afa355d83567d5a8

Reaktionsgleichung

NC(=S)NC1(c2ccc(Cl)cc2)CCC1
N-[1-(4-chlorophenyl)cyclobutyl]thiourea
CCOC(=O)C1(Br)CCC1
ethyl 1-bromocyclobutanecarboxylate
→
O=C1N=C(NC2(c3ccc(Cl)cc3)CCC2)SC12CCC2
6-{[1-(4-Chlorophenyl)cyclobutyl]amino}-5-thia-7-azaspiro[3.4]oct-6-en-8-one

Edukte

NC(=S)NC1(c2ccc(Cl)cc2)CCC1
N-[1-(4-chlorophenyl)cyclobutyl]thiourea
CCOC(=O)C1(Br)CCC1
ethyl 1-bromocyclobutanecarboxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeSynthesis

Vorschrift

Synthesis was performed from N-[1-(4-chlorophenyl)cyclobutyl]thiourea and ethyl 1-bromocyclobutanecarboxylate according to Method D.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541592B2uspto-grants-2013_09