Reaktion #74325

ord-064c10a8730a4507b8c96360c606469f

Reaktionsgleichung

CC1(C)C(NC(N)=S)C1(C)C
N-(2,2,3,3-tetramethylcyclopropyl)thiourea
CCOC(=O)C1(Br)CCC1
ethyl 1-bromocyclobutanecarboxylate
→
CC1(C)C(NC2=NC(=O)C3(CCC3)S2)C1(C)C
6-[(2,2,3,3-Tetramethylcyclopropyl)amino]-5-thia-7-azaspiro[3.4]oct-6-en-8-one

Edukte

CC1(C)C(NC(N)=S)C1(C)C
N-(2,2,3,3-tetramethylcyclopropyl)thiourea
CCOC(=O)C1(Br)CCC1
ethyl 1-bromocyclobutanecarboxylate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeSynthesis

Vorschrift

Synthesis was performed from N-(2,2,3,3-tetramethylcyclopropyl)thiourea and ethyl 1-bromocyclobutanecarboxylate according to Method D.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08541592B2uspto-grants-2013_09